Transformation mechanisms of iopamidol by iron/sulfite systems: Involvement of multiple reactive species and efficiency in real water

Abstract

Although the ability of iron/sulfite system for decontamination purposes has been investigated, the complex reactive species generated and the underlying transformation mechanisms remain elusive. Here, we have comprehensively examined the transformation of iopamidol (IPM), a representative of iodinated X-ray contrast media, by iron catalyzed sulfite oxidation process under different water chemistry conditions. Multiple reactive intermediates including Fe(IV), SO4•−, and SO5•− were identified by conducting a series of experiments. Eight transformation products were detected by mass spectrometry analysis, and correlation with the nature of involved reactive species has been made. Further, the transformation pathways including amide hydrolysis, deiodination, amino and hydroxyl groups oxidation were proposed. Interestingly, these transformation products could be removed through adsorption to iron precipitates formed via pH adjustment. Combining Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, we revealed an effective way to reduce the amount of transformation products in the treated solutions. Since the iron/sulfite process appears to be less sensitive to natural organic matter, it exhibited very good efficiency for IPM removal in real water samples, even with a high organic carbon loading. These findings may have strong implications in the development of novel oxidation process based on the sulfite/iron systems for wastewater treatment.