Abstract
Chick embryo fibroblasts contain 4 types of sialosylglycolipids (SL-1, SL-2, SL-3 and SL-4), 1 neutral glycolipid (glucosylceramide, G-C), and a ceramide (C). SL-1 and SL-2 were identified as hematoside and disialohematoside respectively. After infection with Rous sarcoma viruses, the following changes occur: (i) The quantities of SL-2 and SL-3 are reduced to barely detectable levels in parallel with the development of neoplastic transformation in the cultures. (ii) A decrease in the quantities of SL-1 follows rather than accompanies transformation. (iii) The precursors, G-C and C, of the decreased glycolipids accumulate in transformed cells. (iv) The turnover rates of SL-1, SL-2, and SL-3 are accelerated in transformed cultures. Infection of chick embryo fibroblasts with RAV induces only minor shifts in the cellular glycolipid profile and does not measurably affect turnover rates. Cell density dependent alterations occur in the levels of some glycolipids but appear minor in comparison to the changes seen in neoplastic transformation. Those glycolipids which show an increase at high cell density in normal cultures are the same which are sharply decreased after transformation.
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