Abstract
IN the study of neoplastic transformation of human cells in culture, the quantitative systems so far described have used only the DNA-containing tumour viruses SV40 (ref. 1) and adenovirus type 12 (ref. 2). Various factors, both genetic3 and environmental4, influence the efficiency of transformation with these viruses. We describe here a quantitative transformation system using an RNA-containing tumour virus, murine sarcoma virus (MSV)5. The transformation of human cells by MSV is inefficient, but in optimal conditions (logarithmically growing cells and certain highly susceptible cell strains) both cell transformation and virus growth can be demonstrated.
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