Abstract
Alcohol use and abuse is a important current issue, in addiction it is a social problem leading to isolation, physical consequences and several pathologies. Alcohol intoxication is correlated to accidents, injuries and violence. Developing effective strategies to prevent, diagnose and cure alcohol abuse is a priority as well as to have sure evidences. Carbohydrate-deficient transferrin (CDT) is the most specific biomarker of alcohol abuse. In this review biochemistry, metabolism and definition are showed. Pre-analytical, analytical and post-analytical phases are discussed In this review several CDT applications in hospital , in rehabilitation and in forensic setting are presented. HPLC, CZE and immunoassay methods are presented. The need of standardization of the measurement of CDT is explained, because defining main target analyte, reference method and materials are important to have the same result with different methods. Some criticisms on the standardization process are showed. Diagnostic sensitivity and specificity are discussed and how correctly calculated the cut off and a correct interpretation of data are reported. Guide-lines by SIBioC-GITF are reminded.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
