Abstract
Abstract: The human skin is the largest organ, is a vital interface with the external environment, and maintains homeostasis through its layered structure of epidermis, dermis, and hypodermis. The epidermis forms a strong barrier against microorganisms, and the dermis consists of essential components like collagen and melanin, and the hypodermis aids in insulation and energy storage. The skin diseases, spanning the epidermis, dermis, and subcutaneous tissue, include psoriasis, dermatitis, acne, hyperpigmentation, and aging. The nanocarrier-based drug delivery, particularly transferosomes, shows promise in treating dermatological conditions. Transfersomes are composed of phospholipids and edge activators, and navigate skin structures with flexibility, enhancing drug permeation. They offer continuous drug release, accommodating both lipophilic and hydrophilic drugs, and respond to osmotic gradients, optimizing transdermal delivery. Despite being non-invasive, formulation challenges and stability issues require attention. Studies demonstrate transferosomes' efficacy in treating conditions like acne, psoriasis, and melasma, demonstrating their potential for targeted drug delivery and overcoming conventional limitations in dermatology.
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