Abstract
We show that thiolated strands displayed on a DNA origami nanostructure can be transferred to a gold surface when the DNA origami tile is deposited onto a self-assembled monolayer (SAM) passivating the surface. Spatial statistical analysis revealed the ink molecule transfer yield to be 70%, comparable to the highest yield achieved with existing DNA-nanostructure-based nanoimprinting methods. The surface passivation reduces nonspecific adsorption and allows high-resolution, label-free characterization of the transferred spatial patterns. Therefore, our method offers a pathway toward forming complex single-molecule nanoarrays for elucidating the structure–function relationships of enzyme cascades and interfacial molecular recognition.
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