Abstract
Resistance against an otherwise lethal challenge with a syngeneic virusinduced lymphoma (ULMC) follows prior subcutaneous (s.c.) injection of suitable doses of live or X-rayed ULMC. Partial protection followed the injection of formolized ULMC or of the inducing virus ULV given s.c. Solidly immune, but not partially protected mice, had spleen cells which could transfer resistance to recipients in a modified Winn test: serum from both groups prolonged the life of recipients of intravenous (i.v.) ULMC, and also showed complement dependent cytoxicity against ULMC in vitro. Lymphoma followed the i.v. but not the s.c. injection of ULV. Neither group of infected mice showed a popliteal lymph node response after footpad injection of X-rayed ULMC, or developed immune spleen cells following ULMC immunization. In addition, mice infected with ULV i.v. could not be protected from ULMC challenge by spleen cells from immune donors.
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