Abstract
LITTLE is known of the transfer of peptides between the maternal and fœtal circulation. In their exhaustive review, Hagermann and Villee1 mention the results of the work of Krzysztoporski2, who showed that simple peptides cross the placental barrier, and those of Knobil and Josimovitch3 that insulin crosses the mono-layered placenta of the rat. Other information on the placental penetration of peptide hormones is sparse and contradictory. High concentrations of oxytocin in maternal blood during parturition have been reported4 and it seemed therefore of interest to investigate the possibility that oxytocin in the maternal circulation might reach the fœtus.
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