Abstract
The maternal-fetal transfer of labetalol, an antihypertensive agent, was investigated in vitro, using dual perfusion of isolated human placental lobules with buffered oxygenated Earle’s salt solution as the perfusate. The transport of antipyrine was studied simultaneously to serve as comparison. In 6 experiments, the labetalol transport represented 0.32 ± 0.03 of antipyrine transport fraction. The placental retention of labetalol at steady state represented 2.27 ± 0.51 times the antipyrine retention. The relatively low labetalol transfer, despite its small molecular weight, may be attributed to its high degree of ionization at physiological pH. This observation agrees with earlier studies that ionization is a predominant factor in limiting the placental transfer of drugs.
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