Abstract
Transfer hydrogenation of ketones in the presence of half sandwich ruthenium (II) complexes bearing imidazoline and benzimidazole ligand
Highlights
The strategies employed in the synthesis of the N-substituted imidazoline and benzimidazole ligands are summarized in Scheme 1
Catalytic hydrogen transfer reactions of ruthenium complexes of N-coordinated imidazoline and benzimidazole ligand are very limited for this reaction
Due to the encouraging application of half sandwich ruthenium compounds in transfer hydrogenation catalysis, we have examined the catalytic activity of the complexes 3a-3f toward reduction of carbonyl group of ketones
Summary
Transfer hydrogenation is a potentially useful protocol for the reduction of carbonyl compounds to their corresponding alcohols, which are key intermediates in pharmaceuticals, perfumes, agrochemicals, materials and fine chemicals.[1,2,3] In transfer hydrogenation, 2-propanol, glycerol, formic acid, and its salts have been employed as the hydrogen source.4-8 2-propanol is a popular reactive solvent for the transfer hydrogenation reactions since it is easy to handle and is relatively non-toxic, environmentally benign and inexpensive.[9,10,11] Transition metal catalyzed transfer hydrogenation of ketones and aldehydes have attracted attention for the relatively benign nature of the reagents and mild reaction conditions employed.12-16Among the different metal catalyzed hydrogenation reactions, ruthenium-based catalytic systems are found to be effective in the transfer hydrogenation of ketones[17] and imines.[18]. We report the synthesis and characterization of novel half sandwich ruthenium complexes with N-substituted imidazoline and benzimidazole ligand and investigated their catalytic performances for the transfer hydrogenation of ketones. Synthesis of N-substituted imidazoline and benzimidazole ligands.
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