Abstract
To achieve fast and accurate cell manipulation in a microfluidic channel, it is essential to know the true nature of its input-output relationship. This paper aims to reveal the transfer function of such a micro manipulation controlled by a macro actuator. Both a theoretical model and experimental results for the manipulation are presented. A second-order transfer function is derived based on the proposed model, where the polydimethylsiloxane (PDMS) deformation plays an important role in the manipulation. Experiments are conducted with input frequencies up to 300 Hz. An interesting observation from the experimental results is that the frequency responses of the transfer function behave just like a first-order integration operator in the system. The role of PDMS deformation for the transfer function is discussed based on the experimentally-determined parameters and the proposed model.
Highlights
IntroductionThe manipulation speed and resolution have been previously achieved up to 130 Hz and 240 nm as moving a micro object in a simple harmonic motion (SHM) on a microfluidic chip [2]
There are various situations where cell manipulation is required in microfluidic applications [1].The manipulation speed and resolution have been previously achieved up to 130 Hz and 240 nm as moving a micro object in a simple harmonic motion (SHM) on a microfluidic chip [2]
One of the advantages is that macro actuator, such as the piezoelectric (PZT) actuator shown in Figure 1, or a linear slider, are commercially available so that it is very convenient to implement them into a manipulation system [3,4]
Summary
The manipulation speed and resolution have been previously achieved up to 130 Hz and 240 nm as moving a micro object in a simple harmonic motion (SHM) on a microfluidic chip [2]. In order to further improve the manipulation speed and accuracy, as well as for a better understanding of the system, it is important to know the transfer function of the system. With such a transfer function, a controller can be customized and optimized based on the system characteristics. One of the advantages is that macro actuator, such as the piezoelectric (PZT) actuator shown in Figure 1, or a linear slider, are commercially available so that it is very convenient to implement them into a manipulation system [3,4]
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