Abstract
A 19-year-old white male with both pemphigus vegetans and chronic mucocutaneous candidiasis was treated with transfer factor (TF) based on possible common pathophysiologic relationships between these disorders and immune abnormalities. He was incompletely responsive to treatment with prednisolone, methotrexate, and topical micronazole. During 77 weeks of TF therapy, the patient showed gradual but continuous improvement of both diseases characterized by periods of complete remission and occasional mild exacerbations. Administration of other drugs was not necessary. When TF was withheld both diseases flared but regressed after reinstituting TF injections. Thus, TF may be therapeutically beneficial in some patients with the milder forms of pemphigus, and a relationship between cellular immune abnormalities correctable by TF and pemphigus is suggested.
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