Abstract
The maternal-fetal and neonatal transfers of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) were measured in the blood and milk of dams and in the blood of newborn and suckling calves. Calf blood toxic equivalent quantities (TEQs) were drastically increased by suckling. Blood concentrations of individual congeners were greater in suckling calves than in newborn calves, excluding octachlorodibenzo- p-dioxin (O 8CDD); O 8CDD did not readily transfer to milk but was readily absorbed by the gastrointestinal tract and remained in systemic circulation longer than other congeners. Congener concentrations in milk were correlated with maternal blood levels, and those in suckling calf blood were dependent on their concentrations in milk. These results suggest that neonatal calves absorb more lipophilic organochlorine compounds than prenatal fetuses, that those compounds that are transferred from dams to calves are associated not only with lipid transport but also with other carriers, and that the distribution of congeners is structure-dependent.
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