Transfer allyl esters to thioesters in solid phase condition: synthesis of peptide thioesters by Fmoc chemistry

Abstract

A method to transfer allyl esters to thioesters under a solid phase condition has been developed to synthesize peptide thioesters. A Fmoc chemistry has been applied to synthesize the peptide allyl esters, which are selectively transferred to the expected peptide thioesters under solid phase synthesis conditions successfully.