Abstract
Transepidermal drug delivery in daylight photodynamic therapy in the treatment of photodamaged skin: a pilot study
Highlights
Daylight photodynamic therapy (PDT) is a recent therapeutic modality for actinic keratoses and field cancerization.The association of techniques to PDT for transepidermal delivery of the photosensitizer is a new option for the treatment of photodamaged skin with actinic keratosis
Based on recent data found in the medical literature, we have proposed this pilot study, which seeks to clinically evaluate the modifications induced by this association (TED + Daylight Photodynamic Therapy (DLPDT)), by comparing different protocols and techniques
On the side treated with a combination of CO2 and methyl aminolevulinate (MAL) + depigmenting agent + vitamin C, there was moderate improvement in texture; minimum improvement in wrinkles and pigmentation. (Table 4)
Summary
Daylight photodynamic therapy (PDT) is a recent therapeutic modality for actinic keratoses and field cancerization.The association of techniques to PDT for transepidermal delivery of the photosensitizer is a new option for the treatment of photodamaged skin with actinic keratosis. Chronic exposure to sunlight increases the incidence of nonmelanoma skin cancer, to be included of actinic keratosis (AK), basal cellular carcinoma and spinocellular carcinoma It is responsible for the photoaging of the skin, observed clinically by the presence of wrinkles, erythema, coarseness, telangiectasia and irregular pigmentation.[1] Among treatment options for photodamaged skin with AK, conventional photodynamic therapy (c-PDT) stands out due to its high efficacy and excellent cosmetic results. Some factors, such as side-effects (pain, erythema and edema), the incubation time of the methyl aminolevulinate (MAL) lasting 3 hours under an occlusive dressing and the need of an artificial lamp for the lighting, may be limiting for patients and doctors.[2, 3]. Pain is either absent or discrete during the lighting, and cutaneous reaction in the period following the procedure, such as erythema and edema, are minimal.[4,5,6,7,8,9,10,11]
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