Abstract
With the goal of establishing epidemiologic indexes to evaluate the clinical evidence for developing a disease-modifying treatment of bone and joint diseases including sarcopenia, we set up a large-scale nationwide cohort study called ROAD (Research on Osteoarthritis/osteoporosis Against Disability) in 2005. We established muscle strength and volume indexes stratified according to gender and age strata. We also clarified the prevalence of sarcopenia and its association with osteoarthritis, pain, and exercise in middle-aged individuals. In addition, we showed that unipedal standing exercise and squatting are effective methods to prevent sarcopenia.
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