Transdermal therapies for Peyronie’s disease

Abstract

Topical treatment of Peyronie’s disease has recently emerged as a noninvasive option to decrease the deformity and pain associated with this disorder. This article reviews the literature on this subject with attention to topical verapamil gel, which has been used extensively in the United States. However, no published independent placebo-controlled trials exist to confirm its beneficial effect. This article also reviews iontophoresis, a form of topical energy therapy also known as electromotive drug administration (EMDA). Topical energy therapy without drug administration has been shown to enhance wound healing as a result of the energy transfer. Recent studies have also examined EMDA therapy with verapamil and other agents to encourage scar remodeling with subsequent reduction in penile deformity for the man with Peyronie’s disease.