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Abstract
Different enhancers were evaluated by measuring in vitro diffusion of aqueous vasopressin solution through excised rat skin after pretreatment with enhancers. Azone was found to be the most effective enhancer studied, increasing the flux about 15 times. Concentrations of Azone higher than 3% v/v did not show any further enhancement of flux. The enhancement of flux by Azone in hairless mouse skin was more dramatic (about 70 times), suggesting that the mechanism of enhancement in hairless mouse skin might be different than in the rat. The effect of Azone was evaluated in vivo using adult vasopressin-deficient Brattleboro rats. Urine was collected at time intervals after topical administration of vasopressin, and urine volume, osmolality and radioactivity were determined. Significant reduction in urine volume and increase in osmolality over a 24 h period confirmed the enhancement of vasopressin absorption in presence of Azone found in vitro.
Published Version
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