Abstract
Terpenes are the most promising natural chemical enhancers used to amplify the transdermal permeation of drugs, among them mo noterpenes and sesquiterpenes have been widely suggested. Permeation enhancement effect of various terpenes (nerolidol, farnesol, limonene, linalool, menthol, geraniol, carvone, fenchone etc.) in various combinations of preparations on ibuprofen (IBU) and its solid dispersions (IBUSD 1 ) from Carbopol 941 gel formulations (0.9 %) were studied. Skin permeation studies and release kinetics have shown farnesol (2.5 and 5 %) and geraniol (2.5 %) had the best permeation enhancement on the release rate of ibuprofen gel. Limonene (2.5 %), gerani ol (2.5 and 5 %) had the best permeation enhancement on the release rate of ibuprofen solid dispersion gel. Ex - vivo studies of ibuprofen gel revealed that farnesol with highest lipophilicity (log P 5.31) significantly (p geraniol (230 o C) and that of ibuprofen solid dispersion gel was limonene (176 o C) > geraniol (230 o C). A ll optimized formulations obeyed the Higuchi release kinetics and non
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