TRANSDERMAL PATCH OF RAMIPRIL LOADED CHITOSAN NANOPARTICLES DISPERSED IN CARBOPOL GEL

Abstract

The main aim to improve the systemic bioavailability of Ramipril by the design of transdermal drug delivery based on chitosan nanoparticles dispersed into gels. When chitosan nanoparticles dispersed into gels consisting of poloxamer and carbopol the resulting formulation exhibited thixotropic behavior with a prolonged drug release properties. Our study demonstrated that the designed nanoparticles gel transdermal delivery system has a potential to improve the systemic bioavailability and the therapeutic efficacy of Ramipril loaded chitosan nanoparticles dispersed in carbopol gels. There is no incompatibility between drug and polymers by performing FTIR and DSC. To characterize the rate controlling membrane of transdermal patches. The thickness ranged between TNPGF1 to F9 0.11 ± 0.05 mm to 0.19 ± 0.07 mm, which indicates that they are uniform in thickness. The different batches of formulations weights variations were relatively good uniformity of weight variations among the various batches was observed, with all formulations and ranged from 1.40 ± 1.2% to 1.78 ± 2.0%. The flatness study showed that all the formulations had the same strip length before and after their cuts, indicating 99% flatness. The tensile strength of the TNPGF1 to TNPGF9 shows the 10.14 ± 1.19 to 12.78 ± 2.45 shows the excellent viscosity. The total amount of drug is present in the transdermal patches of TNPGF1 to TNPGF9 was found to be 90.5 ± 0.3 % to 98.5 ± 0.1 %. In-vitro Franz’s diffusion drug Release Studies of among all formulations best formulation TNPGF6. The drug release through the transdermal patches of Ramipril, follows first order kinetics with diffusion controlled mechanism. Keywords: Ramipril, Nanoparticles, Gels, Folding endurance, Tensile strength.Â