Abstract
Transdermal drug delivery systems are preferred for both local and systemic effects. Administration of therapeutic agents with these drug delivery systems provides controlled and sustained release. Among these delivery systems, nanoparticles have a very common use. The use of polymers with different properties can determine the characteristics of nanoparticles such as size, surface charge, and drug release profile and can be modified for passage through the skin. Diffusion cells are the gold standard for skin permeation studies of drugs incorporated with topical or transdermal delivery systems, and Franz diffusion cells are the most ones. The evaluation of penetration of drugs into the skin is important for topical formulations where the expected effect is targeted to the superficial layers of the skin. Tape stripping and microscopic and spectroscopic methods can be used to evaluate skin penetration.
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