Abstract
The bilayer skin/two-compartment body model was used to correlate in vitro skin permeation data and in vivo plasma level data after transdermal delivery of verapamil. A good correlation was found between the transient-state profiles of the experimental and simulated data. However, the experimental steady-state concentrations were lower than the predicted values. This could be explained on the basis that verapamil was undergoing bioconversion in human skin. The mathematical model used also provides an estimate of the rate constant for the metabolism of verapamil in the skin.
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