Abstract

Disruption of body homeostatic mechanisms that necessitate initiation of life-support therapy can result from a variety of biological insults. One commonly encountered cause is infection. Severe infections resulting in damage to distant body organs are a major cause of death and morbidity worldwide. This combination, known as sepsis, arises from a variety of pathogens and manifests in various ways.1 Sepsis is a leading cause of death, accounting for an estimated 20% of all deaths globally in 2017.

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