Abstract
The high-quality brush hair, or Type III brush hair, is coarse hair but with a tip and little medulla, which uniquely grows in the cervical carina of Chinese Haimen goat (Capra hircus). To unveil the mechanism of the formation of Type III brush hair in Haimen goats, transcriptomic RNAseq technology was used for screening of differentially expressed genes (DEGs) in the skin samples of the Type III and the non-Type III hair goats, and these DEGs were analysed by KEGG pathway analysis. The results showed that a total of 295 DEGs were obtained, mainly from three main functional types: cellular component, molecular function and biological process. These DEGs were mainly enriched in three KEGG pathways, such as protein processing in endoplasmic reticulum, MAPK, and complement and coagulation cascades. These DEGs gave hints to a possible mechanism, under which heat stress possibly initiated the formation. The study provided some useful biological information, which could give a new view about the roles of certain factors in hair growth and give hints on the mechanism of the formation of the Type III brush hair in Chinese Haimen goat.
Highlights
High-quality (Type III) brush hair is coarse hair that grows on the cervical carina of Haimen goats
Research works on differential display at the mRNA [8] and proteomic levels [9] have revealed that the formation of Type III brush hair is initiated by androgens and heat stress, or in some cases cold stress, which activates and modulates protein synthesis involved in the formation stage of hair growth
Other differentially expressed genes (DEGs) associated with hair growth and regulation included CaM, TUBA, FLNA UFD1, HSPs, SERPINC1 and MARCH6 (E3 ubiquitin-protein ligase membrane-associated RING finger 6)
Summary
High-quality (Type III) brush hair is coarse hair that grows on the cervical carina of Haimen goats. Research works on differential display at the mRNA [8] and proteomic levels [9] have revealed that the formation of Type III brush hair is initiated by androgens and heat stress, or in some cases cold stress, which activates and modulates protein synthesis involved in the formation stage of hair growth. Through studying DEGs from RNA sequencing assays and several established signalling pathways, a possible mechanism for the formation of Type III brush hair is proposed
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