Abstract
Oxidative stress in the brain occurs when antioxidant systems, such as reduced glutathione (GSH), are overwhelmed by pro-oxidant species, resulting in damage to fundamental cellular components and impaired neuronal functioning. Insufficient GSH is proposed as a pathogenic mechanism contributing to cortical neuronal dysfunction in schizophrenia (SZ). To investigate this possibility, we first quantified markers of the glutathione system and oxidative damage to lipids utilizing quantitative mass spectrometry in the dorsolateral prefrontal cortex (DLPFC) of SZ subjects. Next, we performed transcriptomic analysis of a gene set indexing multiple antioxidant systems in DLPFC gray matter in SZ.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
