Abstract
Nontypeable Haemophilus influenzae (NTHi) is a major bacterial cause of exacerbations in chronic obstructive pulmonary disease (COPD). Here, we report high-depth coverage transcriptome sequencing (RNA-seq) data from two NTHi strains, each encoding a different phase-variable methyltransferase. modA phase variation results in gene expression differences. These data will serve as an important resource for future studies.
Highlights
All methods used for transcriptome sequencing (RNA-seq) are identical to those described previously [12], except we used 100-bp paired-end sequence reads
Previous work examining Nontypeable Haemophilus influenzae (NTHi) pathobiology showed that phase-variable modA genes, encoding DNA methyltransferases, are involved in virulence by epigenetically regulating multiple genes [3,4,5,6]
ModA allelic variants are defined by variation (Ͻ25% identity between alleles) in their central target recognition domain (TRD)
Summary
All methods used for transcriptome sequencing (RNA-seq) are identical to those described previously [12], except we used 100-bp paired-end sequence reads. Nontypeable Haemophilus influenzae (NTHi) is a major bacterial cause of exacerbations in chronic obstructive pulmonary disease (COPD). We report high-depth coverage transcriptome sequencing (RNA-seq) data from two NTHi strains, each encoding a different phase-variable methyltransferase.
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