Abstract
Transcriptional regulators are highly dynamic modulator proteins that bind to the specific DNA targets. These achieve their regulatory effects via activators or promoters. Consequently, the gene transcription is either upregulated or downregulated. These are known to be an integral component of the cell signaling and signal transduction cascade. CodY is a DNA-binding protein that regulates the transcription of several genes involved in crucial cellular activities. Bacillus anthracis is a potent biowarfare agent. Within the bacterium, the CodY targets include genes involved in metabolism, amino acid biosynthesis and transport, nitrogen assimilation, motility, biofilm formation, sporulation, and virulence. Owing to the vitality of the CodY protein in its anthrax pathogenesis, it becomes pertinent to broaden our horizon on its structural and functional attributes.
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