Abstract
Objective: TCDD, also known as dioxin, is the archetype of a family of related polychlorinated compounds found ubiquitously in the environment. Exposure of primates to TCDD may enhance the development of endometriosis. We recently demonstrated significantly increased expression of a TCDD target gene, namely CYP1A1 in endometriotic tissue compared with the eutopic endometrium. We also demonstrated the promoter activity of the CYP1A1 gene in an endometrial cancer cell line and a benign endometrial stromal cell line. We hypothesize that P4501A1 enzyme, the product of the CYP1A1 gene, may promote the development and growth of endometriotic tissue by either activating procarcinogens or catalyzing conversion of estrogens to catechol estrogens. The objective of this study is to define the distribution of P4501A1 protein in eutopic endometrial and endometriotic tissues and the transcriptional regulation of the CYP1A1 gene in eutopic endometrial and endometriotic stromal cells in primary culture.
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