Abstract
Intrinsic disorder plays a crucial role in the NFκB/IκB/DNA genetic regulatory network. Past studies on intrinsic disorder in the NFκB-IκB interaction have been focusing on IκB, the inhibitor of NFκB, while the dynamics of NFκB itself remains little understood. Previous coarse-grained energy landscape models and hydrogen-deuterium exchange mass spectrometry (HDXMS) experiments showed intrinsic disorder in the N-terminal DNA-binding domain (NTD) of NFκB which becomes “locked” upon binding of DNA or IκB.
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