Abstract
Background CD4 T-lymphocytes play a prominent role in Type 1 DM. The NOD mouse is a model for this autoimmune disease. The earliest histological signs of autoimmunity in female NOD mice occur at approximately 5 weeks of age. We hypothesized that this process may be preceded by molecular events in the CD4 T-lymphocytes. To test this hypothesis, we analyzed the transcriptomes of CD4 Tlymphocytes of young prepathologic NOD mice.
Highlights
CD4 T-lymphocytes play a prominent role in Type 1 DM
The earliest histological signs of autoimmunity in female NOD mice occur at approximately 5 weeks of age. We hypothesized that this process may be preceded by molecular events in the CD4 T-lymphocytes
We analyzed the transcriptomes of CD4 Tlymphocytes of young "prepathologic" NOD mice
Summary
CD4 T-lymphocytes play a prominent role in Type 1 DM. The NOD mouse is a model for this autoimmune disease. The earliest histological signs of autoimmunity in female NOD mice occur at approximately 5 weeks of age. We hypothesized that this process may be preceded by molecular events in the CD4 T-lymphocytes. To test this hypothesis, we analyzed the transcriptomes of CD4 Tlymphocytes of young "prepathologic" NOD mice
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