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Abstract
In a mouse infection model with the nematode Heligmosomoides polygurus (Hp), TH2 responses require CXCR5+ DC. The significance of CXCR5+ DCs in TH1 or TH17 infections is unknown. We probed the transcriptomes of migratory DCs in response to Hp (TH2), Citrobacter rodentii (Cr) (TH17), and Leishmania major (Lm) infection (BALB/c mice: TH2, C57BL/6 mice: TH1). We further parsed the transcriptomics of draining lymph node DCs to identify gene signatures associated with CXCR5+ DC.
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