Abstract
The Epstein-Barr virus (EBV) BamHI A rightward transcripts (BARTs) wereoriginally identified in C15 xenograft of nasopharyngeal carcinoma (NPC) and easilydetected in a wide variety of EBV latent infection and EBV-associated tumors. It hadbeen reported that p31 cosmid containing BARTs immortalized monkey epithelial cells,but which particular gene among BARTs family participates in the transformationprocedure remains to be identified. RPMS1 is the only full-length cDNA confirmed so farand one of the most abundant spliced forms in BARTs family. To investigate theinvolvement of RPMS1 gene in NPC, we examined the expression of RPMS1 transcriptsin NPC biopsies from Guangdong and its oncogenic potential. Our results revealed thatRPMS1 mRNA preferentially expressed in primary NPC to non-carcinoma tissue ofnasopharynx and peripheral blood lymphocytes (PBLs) of NPC patients. Furthermore, byintroducing RPMS1 ORF into HEK293 cells, these transfectants enhanced theanchorage-independentPPgrowth and produced tumors in nude mice. These data imply thatRPMS1 gene might play an important role in the development of NPC.
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