Abstract
A critical role has been recognized for the placenta in the development of congenital heart defects (CHD), for which infants of pregestationally diabetic (PGDM) mothers are at pronounced risk. PGDM induces stark histological and gross anatomical changes in the placenta, yet little is known about the PGDM placenta’s role in CHD. High-throughput transcriptomic processes have enabled large-scale association between the gene expression signatures of the heart, placenta, and diabetic state. However, limited integrative data exists, necessitating a comparative appraisal of existing literature to identify placental and cardiac signaling pathways that may be altered in the PGDM state.
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