Abstract
The viruses that infect animal cells, particularly those viruses that replicate in the nucleus of cells, have provided important models for the study of transcriptional regulation. The adenovirus E1A gene encodes proteins that regulate both viral and cellular transcription. Recent studies have provided insights into the molecular mechanisms for transcriptional control by the E1A proteins that include interactions with various cellular transcription factors. Moreover, these studies have also helped to illuminate at least a part of the process by which the E1A 12S product functions as an oncogene.
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