Abstract
Within the past year, structures have been determined for five transcription factors, each of which is a member of a different structural class. Papilloma virus E2 and the TFIID TATA-binding protein represent novel and unanticipated DNA-binding motifs. The GAL4 protein is a new kind of metal-binding domain, GCN4 is a basic-region leucine zipper protein, and MATα2 is a member of the homeodomain family. With the exception of TFIID, the structures of the DNA-bound protein have been determined, revealing how each of the folds is used to recognize specific DNA sequences.
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