Abstract
Activation of the nuclear factor kappa β (NF-κβ) is related to many inflammatory diseases, including age-related macular degeneration (AMD). The imbalance in the redox state, which happens mainly in senescence, associated with several peculiar characteristics of the macular region, has led to studies of this molecule for AMD therapeutic interventions. Findings report the involvement of NF-κβ both in the triggering as well as in the worsening condition of AMD. The present article correlates AMD oxidant and inflammatory genesis with the action of the nuclear factor kappa β. Besides its mechanism of action, this study also analyzes the main inflammatory cytokines and adhesion molecules that may be activated by NF-κβ and are closely related to AMD.
Highlights
Macular DegenerationRogil Jose De Almeida Torres a , Rogerio Torres b, Andrea Luchini c, Ana Lucia Dos Anjos Ferreira a a Faculdade Estadual de Botucatu – UNESP, Brazil
Age-related macular degeneration is the main cause of irreversible loss of vision in the elderly in developed countries [1,2]
The results indicated that the signal transducer and activator of transcription 3 (STAT3) and NF‐κβ signaling pathways might interact with each other and play important roles in IL‐2‐induced fibrosis in retinal pigment epithelial (RPE) cells together
Summary
Rogil Jose De Almeida Torres a , Rogerio Torres b, Andrea Luchini c, Ana Lucia Dos Anjos Ferreira a a Faculdade Estadual de Botucatu – UNESP, Brazil. B Department of Ophthalmology - Hospital Angelina Caron, Brazil.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
