Abstract

Our data demonstrate TRF2 occupancy at the p21, as well as other promoters tens of Mb away from telomeres, to be dependent on telomere length. Of particular interest was the finding that p21 activation, following DNA damage, was transcriptionally regulated by TRF2 in a telomere‐length dependent fashion. Earlier studies have reported transcription to be telomere‐dependent in regions close to telomeres (subtelomeric) through primarily epigenetic mechanisms known as telomere‐positioning‐effect or TPE, which is unlikely to explain telomere‐dependent transcription tens of Mb from telomeres. Our results suggest a novel model of telomere‐dependent gene transcription involving telomere length in partitioning interstitial TRF2 binding.Support or Funding InformationWellcome Trust ‐ Department of Biotechnology India Alliance and Council of Scientific and Industrial Research

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