Abstract
![Figure][1] CREDIT: BURMANN ET AL. In bacteria, translation of messenger RNA into proteins by the ribosome usually begins soon after the ribosome binding site emerges from RNA polymerase. Now there is evidence for direct coupling between transcription and translation in bacteria. Proshkin et al. (p. [504][2]; see the Perspective by [Roberts][3] ) show that the trailing ribosome controls the rate of transcription by preventing RNA polymerase from spontaneous backtracking, which allows precise adjustment of transcriptional yield to translational needs under various growth conditions. Burmann et al. (p. [501][4]; see the Perspective by [Roberts][5] ) provide a potential mechanism for coupling by showing that the transcription factor NusG, which binds RNA polymerase through its amino-terminal domain, competitively binds either a ribosomal protein or the Rho transcription termination factor through its carboxy-terminal domain. Rho binding might occur after release of the ribosome from messenger RNA, thus linking termination of transcription and translation. [1]: pending:yes [2]: /lookup/volpage/328/504 [3]: /lookup/volpage/328/436?iss=5977 [4]: /lookup/volpage/328/501 [5]: /lookup/doi/10.1126/science.1189971
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