Transcript levels of complement regulatory proteins (CD35 and CD59) in rheumatoid arthritis patients and their relationship with disease activity and prognosis

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Event Abstract Back to Event Transcript levels of complement regulatory proteins (CD35 and CD59) in rheumatoid arthritis patients and their relationship with disease activity and prognosis Devyani Anand1, Maumita Kanjilal2, Satbir Kaur2, Uma Kumar2 and Nibhriti Das1* 1 All India Institute of Medical Sciences (AIIMS), Biochemistry, India 2 All India Institute of Medical Sciences (AIIMS), Medicine, India Objectives: Complement regulatory proteins (CRPs) protect the host from tissue injury mediated by activated complement system. In rheumatoid arthritis (RA) exaggerated complement activation is the key event, due to which CRPs CD35 and CD59 may influence the disease pathology and prognosis. Therefore, we aimed at elucidating the leukocyte-CD35 (L-CD35) and L-CD59 transcript levels and the relationship of these two CRPs with the disease activity of RA patients. Methods: 66 controls and 45 RA patients were recruited for this study. Out of 45 RA patients, 11 patients volunteered for the longitudinal study. L-CD35 and L-CD59 transcript levels were determined by real-time PCR and correlated with Circulating immune complexes (CIC) levels and Disease Activity Score-28 (DAS28). Results: Transcript levels of L-CR1 (p < 0.05) and L-CD59 (p < 0.01) were lowered in patients as compared to controls. In longitudinal study, L-CR1 transcript levels (p < 0.05) increased in patients which responded to treatment which correlated with lowered CIC levels (p < 0.05) and DAS28 scores (p < 0.05) at W24 as compared to W0. No significant difference was observed for L-CR1 transcript levels in non-responder group and for L-CD59 transcript levels in responder and non-responder group at W24 as compared to W0. Conclusions: This is the first study to assess the L-CR1 and L-CD59 transcript levels in RA patients. The findings indicate an intimate relation of L-CD35 transcript levels with the disease activity and prognosis in RA patients, and thus suggest L-CD35 transcript as a potential disease marker in RA. Keywords: Rheumatoid arthritis, complement regulatory proteins, Circulating immune complexes, prognosis, disease marker Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Anand D, Kanjilal M, Kaur S, Kumar U and Das N (2013). Transcript levels of complement regulatory proteins (CD35 and CD59) in rheumatoid arthritis patients and their relationship with disease activity and prognosis. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00379 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Nibhriti Das, All India Institute of Medical Sciences (AIIMS), Biochemistry, New Delhi, Delhi, 110029, India, nibhriti@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Devyani Anand Maumita Kanjilal Satbir Kaur Uma Kumar Nibhriti Das Google Devyani Anand Maumita Kanjilal Satbir Kaur Uma Kumar Nibhriti Das Google Scholar Devyani Anand Maumita Kanjilal Satbir Kaur Uma Kumar Nibhriti Das PubMed Devyani Anand Maumita Kanjilal Satbir Kaur Uma Kumar Nibhriti Das Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.