Abstract
Although the transmission of ultrasound (US) through the skull bone has been demonstrated for both therapeutic and imaging applications, the clinical efficacy of certain transcranial US applications remains limited by the highly attenuating properties of skull bone. For those applications, the ability to pre-procedurally determine those areas of the skull that are less attenuating to US could be a tremendous asset for improving the use of US in the brain. To present a possible solution, we have hypothesized that the optical transmission intensity at points across the skull surface can be correlated with the local US transmission efficiency. The demonstration of this correlation would potentially allow for the use of integrated lasers and photodetectors within a HIFU system to create a patient-specific transmission map of the skull. We have statistically investigated the relationship between transmitted optical and US intensities over multiple points across several ex vivo human calvaria to demonstrate this correlation. Along with the results of the analysis, preliminary designs to incorporate optical transmission assessment in transcranial HIFU and echoencephalography will be presented.
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