Abstract
AbstractBackgroundTranscranial Pulse Stimulation (TPS) uses shockwaves for the treatment of Alzheimer´s Disease (AD). Our group published short term results after the first treatment cycle (Cont et al. 2022). Long term data has not been reported yet.Methods25 TPS‐treated patients were examined. All patients received 4Hz TPS of about 6000 pulses of 0.2 mJ/mm2 (navigated bifrontally, biparietally, bitemporally and praecuneus) using the Neurolith System (Storz Medical). After the initial treatment cycle over 2 weeks patients receive monthly booster sessions. Cognitive scores (ADAS, MMST, MoCA) are available up to 6 (n = 10) and 12 months (n = 5).ResultsCognition showed significant improvement in all scores after initial treatment across patients. Mean scores where stable over 12 months. Effects varied between patients.Discussion / ConclusionThe initial improvement of cognitive functions can be maintained up to 12 months in this retrospective. Prospective controlled trials need to done as next step.
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