Abstract
Abstract We report a case of transcortical mixed aphasia associated with left thalamic glioblastoma. A 60-year-old right-handed woman was admitted to our hospital with speech disturbance and right hemiparesis. She was alert and well oriented. However, spontaneous speech was remarkably reduced, and object naming, word fluency, verbal comprehension, reading and writing were all severely disturbed. However, repetition of phonemes and sentences was fully preserved. CT scan revealed a huge tumour in the left thalamus. The rCBF (regional cerebral blood flow) study and 99mTc-HM-PAO SPECT (single-photon emission CT) showed a low-flow area in the entire left hemisphere. It is possible that rCBF does not necessarily reflect cerebral function, so that function in the tumour area may be retained even in the presence of reduced rCBF caused by a brain tumour. In this case, reduced linguistic ability might have reflected compensation by the contralateral hemisphere.
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