Abstract
The research focuses on the effectiveness of transluminal laser revascularization of the brain in the treatment of atherosclerotic lesions accompanied by vascular dementia development. 1125 patients aged from 29 to 81 (average age 75) suffering from various kinds of atherosclerotic lesions of cerebral vessels were examined during the research. The examination plan included: computed tomography of the brain (CT), magnetic resonance imaging (MRI), scintigraphy of the brain (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA). 665 (59.11%) patients suffered from diseases accompanied by the development of vascular dementia. To perform transcatheter treatment, 639 patients were selected: Group 1 (CDR-1)—352 patients, Group 2 (CDR-2)—184 patients, Group 3 (CDR-3)—103 patients. To conduct revascularization of main intracranial arteries high-energy laser systems were used; for revascularization of the distal intracranial branches low-energy laser systems were used. The clinical outcome depended on the severity of dementia and the timing of the intervention. A good clinical outcome in Group 1 was obtained in 281 (79.82%) cases, in Group 2 in 81 (44.02%) cases, in Group 3 in 9 (8.73%) cases. A satisfactory clinical outcome in Group 1 was obtained in 53 (15.34%) cases, in Group 2 in 62 (33.70%) cases, in Group 3 in 31 (30.09%) cases. A relatively satisfactory clinical outcome in Group 1 was obtained in 17 (4.83%) cases, in Group 2 in 41 (22.28%) cases, in Group 3 in 63 (61.16%) cases. No negative effect was observed after the intervention. Evaluating the data obtained it can be concluded that the method of transluminal laser revascularization of cerebral blood vessels is an effective one for the treatment of atherosclerotic lesions of the brain accompanied by dementia.
Highlights
Cerebrovascular diseases occupy one of the leading positions on mortality among the population and are among the major causes of disability affecting middle-aged and senior citizens [1]
The research focuses on the effectiveness of transluminal laser revascularization of the brain in the treatment of atherosclerotic lesions accompanied by vascular dementia development. 1125 patients aged from 29 to 81 suffering from various kinds of atherosclerotic lesions of cerebral vessels were examined during the research
Evaluating the data obtained it can be concluded that the method of transluminal laser revascularization of cerebral blood vessels is an effective one for the treatment of atherosclerotic lesions of the brain accompanied by dementia
Summary
Cerebrovascular diseases occupy one of the leading positions on mortality among the population and are among the major causes of disability affecting middle-aged and senior citizens [1]. Lesions of the brain vascular system vary considerably and lead to motor and sensory disturbances and contribute to the development of secondary neurodegenerative changes, mental disorders and dementia [2]. According to “The Seventh International Congress on Vascular Dementia”, the development of vascular dementia (VaD) is mostly associated with atherosclerotic lesions of some or other parts of cerebrovascular bed. The capillary bed plays the leading part in cerebral cells blood supply; pathologically, the capillary and collateral bed, which has capillaries of its own, does. The number of capillaries in a cubic centimeter of brain tissue makes 3 - 4 thousand [3]. The brain can be described as an organ with the highest level of blood supply
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