Transcallosal motor disinhibition to transcranial magnetic stimulation in de novo patients with Celiac disease

Abstract

Celiac disease (CD) may present or be complicated by neurological and neuropsychiatric manifestations. Transcranial magnetic stimulation (TMS) non-invasively probes brain excitability, even in preclinical stages. We previously demonstrated an intracortical motor disinhibition and hyperfacilitation in de novo CD patients, which revert back after long-term gluten-free diet (GFD). In the present study we explored the intercortical excitability by transcallosal inhibition, which has never been investigated in CD.