Abstract
As Alzheimer’s disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.
Highlights
Alzheimer’s disease (AD) affects many cellular and molecular targets and requires multi-target molecules for therapeutics
Resveratrol (3,5,4’-trihydroxy-trans-stilbene), a polyphenol of the stilbene family was studied for its effects in AD, because it was described as an antiinflammatory drug [4], able to inhibit amyloid β (Aβ) aggregation [5] and Aβ-induced neuronal apoptosis [6]
We demonstrated that trans ε-viniferin both induced the disaggregation of Aβ42 peptide and inhibited inflammation on murine primary neuronal cultures with a higher efficiency than resveratrol [11]
Summary
Alzheimer’s disease (AD) affects many cellular and molecular targets and requires multi-target molecules for therapeutics. Polyphenols are natural substances obtained from plants, fruits and vegetables that can be found in beverages. Resveratrol (3,5,4’-trihydroxy-trans-stilbene), a polyphenol of the stilbene family was studied for its effects in AD, because it was described as an antiinflammatory drug [4], able to inhibit Aβ aggregation [5] and Aβ-induced neuronal apoptosis [6]. This natural stilbenoid is very rapidly metabolized, and it would be necessary to administrate very high doses daily [7]
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