Abstract
(−)- Trans-ε-viniferin (ε-viniferin, 5–200 μM), a dimer of resveratrol, concentration-dependently inhibited the uptake of [ 3H]noradrenaline and [ 3H]5-HT by synaptosomes from rat brain (being slightly but significantly more selective against [ 3H]noradrenaline) and the uptake of [ 3H]5-HT by human platelets. On the other hand, ε-viniferin (5–200 μM) concentration-dependently inhibited the enzymatic activity of commercial (human recombinant) monoamine oxidase (MAO) isoform (MAO-A and MAO-B) activity, being slightly but significantly more selective against MAO-B than against MAO-A. Taking into account that the principal groups of drugs used to treat major depression are noradrenaline/5-HT uptake or MAO inhibitors, under the assumption that ε-viniferin exhibits a similar behaviour in humans in vivo, our results suggest that this natural polyphenol may be of value as a structural template for the design and development of new antidepressant drugs with two important biochemical activities combined in the same chemical structure: noradrenaline/5-HT uptake and MAO inhibitory activity.
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