Abstract
Our aim was to explore the effects of the anti-allergic and antifibrotic agent tranilast on chronic cyclosporine (CsA) nephrotoxicity in rats. Methods Eighteen Sprague-Dawley rats were randomized to be given the following daily treatments by gavage for 4 weeks: (1) controls, olive oil; (2) CsA group, CsA 25 mg/kg; (3) CsA plus tranilast group, CsA 25 mg/kg and tranilast 400 mg/kg. We examined the body weights and the effects of tranilast on histopathology, macrophage (Mϕ) infiltration, and expression of osteopontin (OPN). Results The administration of tranilast improved body weight gain by CsA-treated rats (232 ± 24 vs 203 ± 6 g; P < .05). This treatment reduced the expression of OPN protein and infiltration of macrophages (9.14 ± 2.7 vs 22.44 ± 5.68 ED-1 positive cells per high power field, P < .05). Furthermore compared with the CsA alone group, it ameliorated tubulointerstitial fibrosis scores (1.18 ± 0.08 vs 2.57 ± 0.21, P < .05). Conclusion Tranilast attenuated tubulointerstitial fibrosis through decreased expression of OPN protein and macrophage infiltration, showing renal protective effects in rats with chronic CsA nephrotoxicity.
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