Abstract
Background Indoleamine 2, 3-dioxygenase (IDO) converts tryptophan in various catabolites and has been shown to induce immune tolerance in different immune-mediated diseases, including organ transplantation. One of these tolerogenic metabolites is anthranilic acid. Tranilast is a clinically approved, structural and functional analogue of anthranilic acid that has been recently shown to be effective in murine models of multiple sclerosis and rheumatoid arthritis. We examined the effect of tranilast in a rat cardiac allograft model. Materials and methods Lewis 1W rat hearts were grafted in MHC-mismatched Lewis 1A rats. The receiver is orally treated with 650mg/kg of tranilast daily for 30 days. Total splenocytes and purified spleen cell subtypes sorted by FACS Aria were transferred to sublethaly irradiated rats by i.v injection the day before transplantation. Results
Highlights
Indoleamine 2, 3-dioxygenase (IDO) converts tryptophan in various catabolites and has been shown to induce immune tolerance in different immune-mediated diseases, including organ transplantation
We examined the effect of tranilast in a rat cardiac allograft model
Total splenocytes and purified spleen cell subtypes sorted by FACS Aria were transferred to sublethaly irradiated rats by i.v injection the day before transplantation
Summary
Indoleamine 2, 3-dioxygenase (IDO) converts tryptophan in various catabolites and has been shown to induce immune tolerance in different immune-mediated diseases, including organ transplantation. One of these tolerogenic metabolites is anthranilic acid. Tranilast is a clinically approved, structural and functional analogue of anthranilic acid that has been recently shown to be effective in murine models of multiple sclerosis and rheumatoid arthritis. We examined the effect of tranilast in a rat cardiac allograft model
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