Abstract
INTRODUCTIONAlthough regularly used as a method to reduce blood loss in elective orthopedic procedures (e.g., total hip and knee arthroplasty), there currently is little evidence concerning the optimal dosage, timing and route for the use of tranexamic acid to reduce postoperative blood loss in hip fracture repair.SUMMARY OF THE EVIDENCEThe current literature suggests that tranexamic acid may be used to reduce postoperative blood loss in addition to reducing the risk of requiring blood transfusions following the surgical repair of hip fractures. Furthermore, it may have the potential to improve patient outcomes and decrease the overall costs of caring for this patient population.CONCLUSIONSFurther studies are needed to truly gauge the effect of tranexamic acid on long-term patient outcomes and hospital costs.
Highlights
Regularly used as a method to reduce blood loss in elective orthopedic procedures, there currently is little evidence concerning the optimal dosage, timing and route for the use of tranexamic acid to reduce postoperative blood loss in hip fracture repair
Hip fractures are commonly associated with a relatively large amount of blood loss from the initial injury in addition to blood loss resulting from surgery.[2]
A range of between 20-60% of patients require blood transfusions after surgery, which may result in an increase in postoperative infections, increased length of hospital stay, and potential increases in admission costs by an average of approximately $1731.2 Serine proteases has been employed in an attempt to control postoperative hemorrhage, but with the risk of anaphylaxis, this option was not ideal.[3]
Summary
Regularly used as a method to reduce blood loss in elective orthopedic procedures (e.g., total hip and knee arthroplasty), there currently is little evidence concerning the optimal dosage, timing and route for the use of tranexamic acid to reduce postoperative blood loss in hip fracture repair
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