Abstract
Main strategies used as first line treatment of aggressive lymphoma are the subject of this review. The evolution of histo-pathogical classifications is reviewed and the concept of aggressive lymphoma is given. General principles of chemotherapy treatment and main pronostic factors that direct therapeutic decisions are described. The treatment modalities of localized and advanced disease are detailed, as well as the role of high-dose therapy with hematopoietic support. Finally, the major impact of immunotherapy based on the monoclonal anti-CD20 antibody is envisaged.
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